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>   首页   >   产品   >   一抗   >   心血管   >   OSM Antibody (C-term)   

OSM Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - OSM Antibody (C-term) AP14525b
    Western blot analysis of lysate from Jurkat cell line, using OSM Antibody (C-term)(Cat. #AP14525b). AP14525b was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P13725
Other Accession NP_065391.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 5008
Other Names Oncostatin-M, OSM, OSM
Target/Specificity This OSM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-243 amino acids from the C-terminal region of human OSM.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsOSM Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OSM
Function Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).
Cellular Location Secreted.
Research Areas

BACKGROUND

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells.

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Thorat Manojkumar, S., et al. Cytokine 50(3):248-252(2010)
Pradeep, A.R., et al. Biomarkers 15(3):277-282(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Lee, G., et al. J. Obstet. Gynaecol. Res. 35(5):869-875(2009)

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