|Application ||WB, IHC-P, E|
|Calculated MW||90273 Da|
|Other Names||Heat sensitive channel TRPV3|
|Target/Specificity||This Rat TRPV3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 662-692 amino acids from the C-terminal region of rat TRPV3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Rat TRPV3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
Provided below are standard protocols that you may find useful for product applications.
TRPV3 belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C.
Frederick,J., Biochem. Biophys. Res. Commun. 358 (4), 1058-1064 (2007)
Asakawa,M., J. Invest. Dermatol. 126 (12), 2664-2672 (2006)