注册 | 登录
所有产品
  • 所有产品
  • 一抗
  • 裂解液
>   首页   >   产品   >   一抗   >   精选抗体   >   BBC3 Antibody (Center)   

BBC3 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - BBC3 Antibody (Center) AP14100c
    BBC3 Antibody (Center) (Cat. #AP14100c) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the BBC3 antibody detected the BBC3 protein (arrow).
  • 14 - BBC3 Antibody (Center) AP14100c
    BBC3 Antibody (Center) (Cat. #AP14100c)immunohistochemistry analysis in formalin fixed and paraffin embedded human cervix tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of BBC3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 产品详情
  • 实验流程
  • 背景知识
Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q9BXH1
Other Accession NP_055232.1, NP_001120714.1, NP_001120713.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 20532 Da
Additional info
Gene ID 27113
Other Names Bcl-2-binding component 3, JFY-1, p53 up-regulated modulator of apoptosis, BBC3, PUMA
Target/Specificity This BBC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-137 amino acids from the Central region of human BBC3.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBBC3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BBC3
Synonyms PUMA
Function Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis (PubMed:11463391). Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis (PubMed:23340338).
Cellular Location Mitochondrion Note=Localized to the mitochondria in order to induce cytochrome c release
Tissue Location Ubiquitously expressed.
Research Areas

BACKGROUND

BBC3 is an essential mediator of p53-dependent and p53-independent apoptosis.

REFERENCES

Cazanave, S.C., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (1), G236-G243 (2010) :
Gurzov, E.N., et al. J. Biol. Chem. 285(26):19910-19920(2010)
Hemmati, P.G., et al. J. Mol. Med. 88(6):609-622(2010)
Gomes, N.P., et al. Genes Dev. 24(10):1022-1034(2010)
Liu, F.T., et al. Biochem. Biophys. Res. Commun. 310(3):956-962(2003)

FeedBack

终于等到您。感谢您使用ABGENT(百奇生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。

如有疑问,联系:0512-69552906 tech.abgent@wuxiapptec.com.


我要评价