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|Application ||WB, E|
|Other Accession||NP_001167598.1, NP_000608.1|
|Reactivity||Human, Mouse, Rat|
|Other Names||Natural resistance-associated macrophage protein 2, NRAMP 2, Divalent cation transporter 1, Divalent metal transporter 1, DMT-1, Solute carrier family 11 member 2, SLC11A2, DCT1, DMT1, NRAMP2|
|Target/Specificity||This SLC11A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-291 amino acids from the Central region of human SLC11A2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC11A2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DCT1, DMT1, NRAMP2|
|Function||Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.|
|Cellular Location||Endosome membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney.|
Author : Mondal M1, Schilling B, Folger J, Steibel JP, Buchnick H, Zalman Y, Ireland JJ, Meidan R, Smith GW.
Physiol Genomics. 2011 Apr 27;43(8):447-56. doi: 10.1152/physiolgenomics.00155.2010. Epub 2011 Feb 15.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Tabuchi, M., et al. J. Cell. Sci. 123 (PT 5), 756-766 (2010) :
Tabuchi, M., et al. Mol. Biol. Cell 13(12):4371-4387(2002)