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>   首页   >   产品   >   一抗   >   信号转导   >   TPM4 Antibody (N-term)   

TPM4 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - TPM4 Antibody (N-term) AP12756a
    TPM4 Antibody (N-term) (Cat. #AP12756a) western blot analysis in U251,A549,Jurkat cell line lysates (35ug/lane).This demonstrates the TPM4 antibody detected the TPM4 protein (arrow).
  • 4 - TPM4 Antibody (N-term) AP12756a
    TPM4 Antibody (N-term) (Cat. #AP12756a) flow cytometric analysis of U251 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • 14 - TPM4 Antibody (N-term) AP12756a
    Formalin-fixed and paraffin-embedded H.breast tissue reacted with TPM4 Antibody (N-term) (Cat#AP12756a).
  • 14 - TPM4 Antibody (N-term) AP12756a
    Formalin-fixed and paraffin-embedded H.skeletal muscle tissue reacted with TPM4 Antibody (N-term) (Cat#AP12756a).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, FC, IHC-P, E
Primary Accession P67936
Other Accession P67937, NP_003281.1
Reactivity Human
Predicted Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 7171
Other Names Tropomyosin alpha-4 chain, TM30p1, Tropomyosin-4, TPM4
Target/Specificity This TPM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-54 amino acids from the N-terminal region of human TPM4.
Dilution WB~~1:1000
FC~~1:10~50
IHC-P~~1:100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTPM4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TPM4
Function Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432).
Cellular Location Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P09495}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P09495}
Tissue Location Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level).
Research Areas

BACKGROUND

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

REFERENCES

Martins-de-Souza, D., et al. J Psychiatr Res 44(14):989-991(2010)
Vlahovich, N., et al. Cell Motil. Cytoskeleton 65(1):73-85(2008)
Montesano Gesualdi, N., et al. Free Radic. Res. 40(5):467-476(2006)
Hossain, M.M., et al. J. Biol. Chem. 280(51):42442-42453(2005)
Bruneel, A., et al. Proteomics 5(15):3876-3884(2005)

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