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SLC23A1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - SLC23A1 Antibody (N-term) AP12718a
    All lanes : Anti-SLC23A1 Antibody (N-term) at 1:1000-1:2000 dilution Lane 1: Caki-1 whole cell lysate Lane 2: HT-29 whole cell lysate Lane 3: SW480 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 65 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - SLC23A1 Antibody (N-term) AP12718a
    SLC23A1 Antibody (N-term) (Cat. #AP12718a) western blot analysis in HepG2(lane 1),NCI-H292(lane 2) cell line lysates (35ug/lane).This demonstrates the SLC23A1 antibody detected the SLC23A1 protein (arrow).
  • 14 - SLC23A1 Antibody (N-term) AP12718a
    SLC23A1 Antibdy (N-term) (Cat. #AP12718a)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SLC23A1 Antibdy (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q9UHI7
Other Accession NP_005838.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 64831 Da
Additional info
Gene ID 9963
Other Names Solute carrier family 23 member 1, Na(+)/L-ascorbic acid transporter 1, Sodium-dependent vitamin C transporter 1, hSVCT1, Yolk sac permease-like molecule 3, SLC23A1, SVCT1, YSPL3
Target/Specificity This SLC23A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SLC23A1.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSLC23A1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC23A1
Synonyms SVCT1, YSPL3
Function Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus
Research Areas
Inhibition of intestinal ascorbic acid uptake by lipopolysaccharide is mediated via transcriptional mechanism(s).
Author : Subramanian VS1,Sabui S2,Moradi H2,Marchant JS3,Said HM2.
Biochim Biophys Acta. 2017 Oct 10. pii: S0005-2736(17)30320-6. doi: 10.1016/j.bbamem.2017.10.010. [Epub ahead of print]
29030247
Glyoxalate reductase/hydroxypyruvate reductase interacts with the sodium-dependent vitamin C transporter-1 to regulate cellular vitamin C homeostasis.
Author : Subramanian VS1, Nabokina SM, Patton JR, Marchant JS, Moradi H, Said HM.
Am J Physiol Gastrointest Liver Physiol. 2013 Jun 15;304(12):G1079-86. doi: 10.1152/ajpgi.00090.2013. Epub 2013 Apr 18.
23599041

BACKGROUND

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

REFERENCES

Timpson, N.J., et al. Am. J. Clin. Nutr. 92(2):375-382(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Michels, A.J., et al. Am. J. Physiol., Cell Physiol. 297 (5), C1220-C1227 (2009) :
Cahill, L.E., et al. J Nutrigenet Nutrigenomics 2(6):292-301(2009)

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