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LPAR6 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - LPAR6 Antibody (Center) AP12707c
    All lanes : Anti-LPAR6 Antibody (Center) at 1:2000 dilution Lane 1: Molt-4 whole cell lysate Lane 2: HepG2 whole cell lysate Lane 3: Mouse heart tissue lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 39 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - LPAR6 Antibody (Center) AP12707c
    All lanes : Anti-LPAR6 Antibody (Center) at 1:1000 dilution Lane 1: Mouse heart tissue lysate Lane 2: Rat heart tissue lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 39 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - LPAR6 Antibody (Center) AP12707c
    LPAR6 Antibody (Center) (Cat. #AP12707c) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the LPAR6 antibody detected the LPAR6 protein (arrow).
  • 14 - LPAR6 Antibody (Center) AP12707c
    LPAR6 Antibdy (Center) (Cat. #AP12707c)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LPAR6 Antibdy (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession P43657
Other Accession Q4G072, Q8BMC0, NP_001155970.1, NP_005758.2
Reactivity Human, Mouse, Rat
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 39392 Da
Additional info
Gene ID 10161
Other Names Lysophosphatidic acid receptor 6, LPA receptor 6, LPA-6, Oleoyl-L-alpha-lysophosphatidic acid receptor, P2Y purinoceptor 5, P2Y5, Purinergic receptor 5, RB intron encoded G-protein coupled receptor, LPAR6, P2RY5
Target/Specificity This LPAR6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-134 amino acids from the Central region of human LPAR6.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLPAR6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LPAR6
Synonyms P2RY5
Function Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes
Research Areas

BACKGROUND

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants.

REFERENCES

Pasternack, S.M., et al. Arch. Dermatol. Res. 301(8):621-624(2009)
Yanagida, K., et al. J. Biol. Chem. 284(26):17731-17741(2009)
Tariq, M., et al. Br. J. Dermatol. 160(5):1006-1010(2009)
Shimomura, Y., et al. J. Invest. Dermatol. 129(3):622-628(2009)
Dereure, O. Ann Dermatol Venereol 135(11):794-795(2008)

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