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SNRPD3 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - SNRPD3 Antibody (N-term) AP12451A
    Anti-SNRPD3 Antibody (N-term) at 1:2000 dilution + COLO 205 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 14 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - SNRPD3 Antibody (N-term) AP12451A
    All lanes : Anti-SNRPD3 Antibody (N-term) at 1:4000 dilution Lane 1: Hela whole cell lysate Lane 2: MCF-7 whole cell lysate Lane 3: 293 whole cell lysate Lane 4: Jurkat whole cell lysate Lane 5: HL-60 whole cell lysate Lane 6: Mouse heart tissue lysate Lane 7: NIH/3T3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 14 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P62318
Other Accession P62323, P62320, O44437, NP_004166.1
Reactivity Human, Mouse
Predicted Xenopus, Drosophila
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 6634
Other Names Small nuclear ribonucleoprotein Sm D3, Sm-D3, snRNP core protein D3, SNRPD3
Target/Specificity This SNRPD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human SNRPD3.
Dilution WB~~1:4000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSNRPD3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNRPD3
Function Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre- catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).
Cellular Location Cytoplasm, cytosol. Nucleus Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Research Areas
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Author : Chan-Penebre E1, Kuplast KG1, Majer CR2, Boriack-Sjodin PA1, Wigle TJ2, Johnston LD1, Rioux N1, Munchhof MJ1, Jin L3, Jacques SL1, West KA1<
Nat Chem Biol. 2015 Apr 27. doi: 10.1038/nchembio.1810. [Epub ahead of print]
25915199

BACKGROUND

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.

REFERENCES

Gonsalvez, G.B., et al. J. Cell Biol. 178(5):733-740(2007)
Ma, Y., et al. Structure 13(6):883-892(2005)
Mahler, M., et al. Arthritis Res. Ther. 7 (1), R19-R29 (2005) :
Ong, S.E., et al. Nat. Methods 1(2):119-126(2004)
Ong, S.E., et al. Nat. Methods 1(2):119-126(2004)

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