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SLC16A3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - SLC16A3 Antibody (C-term) AP12397b
    All lanes : Anti-SLC16A3 Antibody (C-term) at 1:1000 dilution Lane 1: Human skeletal muscle tissue lysate Lane 2: Rat skeletal muscle tissue lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 49 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - SLC16A3 Antibody (C-term) AP12397b
    All lanes : Anti-SLC16A3 Antibody (C-term) at 1:1000-1:2000 dilution Lane 1: NCI-H460 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: HCT116 whole cell lysate Lane 4: Neuro-2a whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 49 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - SLC16A3 Antibody (C-term) AP12397b
    All lanes : Anti-SLC16A3 Antibody (C-term) at 1:2000 dilution Lane 1: Human skeletal muscle tissue lysate Lane 2: C2C12 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 49 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 14 - SLC16A3 Antibody (C-term) AP12397b
    SLC16A3 Antibody (C-term) (Cat. #AP12397b)immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SLC16A3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, WB, E
Primary Accession O15427
Other Accession O35910, P57787, NP_001035887.1, NP_001035888.1
Reactivity Human, Mouse, Rat
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 9123
Other Names Monocarboxylate transporter 4, MCT 4, Solute carrier family 16 member 3, SLC16A3, MCT4
Target/Specificity This SLC16A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 433-462 amino acids from the C-terminal region of human SLC16A3.
Dilution WB~~1:2000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSLC16A3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC16A3
Synonyms MCT4
Function Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Highly expressed in skeletal muscle.
Research Areas

BACKGROUND

Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Vellonen, K.S., et al. Eur J Pharm Sci 39(4):241-247(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Wang, Q., et al. Drug Metab. Dispos. 35(8):1393-1399(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)

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