- 文献引用 : 1
|Application ||FC, WB, IF, IHC-P, E|
|Other Names||Periostin, PN, Osteoblast-specific factor 2, OSF-2, POSTN, OSF2|
|Target/Specificity||This POSTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 687-716 amino acids from the C-terminal region of human POSTN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||POSTN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.|
|Cellular Location||Golgi apparatus. Secreted, extracellular space, extracellular matrix. Note=Colocalizes with BMP1 in the Golgi.|
|Tissue Location||Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor Overexpressed in breast cancers.|
Author : Park SY1, Piao Y1, Jeong KJ2, Dong J1, de Groot JF3.
Mol Cancer Ther. 2016 Jun 15. pii: molcanther.0427.2015. [Epub ahead of print]
Provided below are standard protocols that you may find useful for product applications.
POSTN binds to heparin. It induces cell attachment and spreading and plays a role in cell adhesion and may play a role in extracellular matrix mineralization.
Zhu, M., et al. Gynecol. Oncol. 119(2):337-344(2010)
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Sidhu, S.S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14170-14175(2010)
Tischler, V., et al. BMC Cancer 10, 273 (2010) :