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KCNRG Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 14 - KCNRG Antibody (C-term) AP11851b
    KCNRG Antibody (C-term) (Cat. #AP11851b)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KCNRG Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 1 - KCNRG Antibody (C-term) AP11851b
    KCNRG Antibody (C-term) (Cat. #AP11851b) western blot analysis in mouse liver,lung tissue lysates (35ug/lane).This demonstrates the KCNRG antibody detected the KCNRG protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, WB, E
Primary Accession Q8N5I3
Other Accession NP_005789.2, NP_001007279.1, NP_775876.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 31048 Da
Additional info
Gene ID 283518
Other Names Potassium channel regulatory protein, Potassium channel regulator, Protein CLLD4, KCNRG, CLLD4
Target/Specificity This KCNRG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-202 amino acids from the C-terminal region of human KCNRG.
Dilution IHC-P~~1:10~50
WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKCNRG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNRG
Synonyms CLLD4
Function Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.
Cellular Location Endoplasmic reticulum
Tissue Location Ubiquitous in normal tissues and expressed in some tumor tissues.
Research Areas

BACKGROUND

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene.

REFERENCES

Lerner, M., et al. Mol. Biol. Cell 18(5):1670-1682(2007)
Skoblov, M., et al. Biochem. Biophys. Res. Commun. 342(3):859-866(2006)
Corcoran, M.M., et al. Genes Chromosomes Cancer 40(4):285-297(2004)
Dunham, A., et al. Nature 428(6982):522-528(2004)
van Everdink, W.J., et al. Cancer Genet. Cytogenet. 146(1):48-57(2003)

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