- 文献引用 : 1
|Application ||WB, E|
|Other Names||Radiation-inducible immediate-early gene IEX-1, Differentiation-dependent gene 2 protein, Protein DIF-2, Immediate early protein GLY96, Immediate early response 3 protein, PACAP-responsive gene 1 protein, Protein PRG1, IER3, DIF2, IEX1, PRG1|
|Target/Specificity||This IER3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the N-terminal region of human IER3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IER3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DIF2, IEX1, PRG1|
|Function||May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
Author : Chen Y1, Huang K, Nakatsu MN, Xue Z, Deng SX, Fan G.
Hum Mol Genet. 2013 Apr 1;22(7):1271-9. doi: 10.1093/hmg/dds527. Epub 2012 Dec 20.
Provided below are standard protocols that you may find useful for product applications.
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.
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Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Fellay, J., et al. PLoS Genet. 5 (12), E1000791 (2009) :
Do, T.N., et al. Cancer Genet. Cytogenet. 195(1):31-36(2009)
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :