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CPM Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CPM Antibody (Center) AP11458c
    Western blot analysis of lysate from human kidney tissue lysate, using CPM Antibody (Center)(Cat. #AP11458c). AP11458c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
  • 1 - CPM Antibody (Center) AP11458c
    Western blot analysis of lysates from U-251 MG, 293T cell line (from left to right), using CPM Antibody (Center)(Cat. #AP11458c). AP11458c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
  • 14 - CPM Antibody (Center) AP11458c
    Formalin-fixed and paraffin-embedded H.adrenal tissue tissue reacted with CPM Antibody (Center) (Cat#AP11458c).
  • 14 - CPM Antibody (Center) AP11458c
    Formalin-fixed and paraffin-embedded H.kidney tissue reacted with CPM Antibody (Center) (Cat#AP11458c).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P14384
Other Accession NP_938079.1, NP_001865.1, NP_001005502.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 1368
Other Names Carboxypeptidase M, CPM, CPM
Target/Specificity This CPM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-241 amino acids from the Central region of human CPM.
Dilution WB~~1:1000
IHC-P~~1:100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCPM Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPM
Function Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor
Research Areas

BACKGROUND

The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq].

REFERENCES

Rietschel, M., et al. Biol. Psychiatry 68(6):578-585(2010) Erickson-Johnson, M.R., et al. Mod. Pathol. 22(12):1541-1547(2009) Marquez-Curtis, L., et al. Stem Cells 26(5):1211-1220(2008) Zhang, X., et al. J. Biol. Chem. 283(12):7994-8004(2008) Elortza, F., et al. J. Proteome Res. 5(4):935-943(2006)

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