|Application ||WB, IHC-P, E|
|Other Accession||NP_938079.1, NP_001865.1, NP_001005502.1|
|Other Names||Carboxypeptidase M, CPM, CPM|
|Target/Specificity||This CPM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-241 amino acids from the Central region of human CPM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CPM Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq].
Rietschel, M., et al. Biol. Psychiatry 68(6):578-585(2010) Erickson-Johnson, M.R., et al. Mod. Pathol. 22(12):1541-1547(2009) Marquez-Curtis, L., et al. Stem Cells 26(5):1211-1220(2008) Zhang, X., et al. J. Biol. Chem. 283(12):7994-8004(2008) Elortza, F., et al. J. Proteome Res. 5(4):935-943(2006)