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|Application ||WB, E|
|Other Names||Phospholemman, FXYD domain-containing ion transport regulator 1, Fxyd1, Plm|
|Target/Specificity||This Mouse PLM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of mouse PLM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse PLM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
Author : Nakajima-Takenaka C1, Zhang GX, Obata K, Tohne K, Matsuyoshi H, Nagai Y, Nishiyama A, Takaki M.
Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1736-43. doi: 10.1152/ajpheart.00672.2009. Epub 2009 Sep 4.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternative splicing of this gene results in multiple transcript variants which encode the same protein.