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Mouse PLM Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - Mouse PLM Antibody (N-term) AP1126a
    Mouse PLM Antibody (E1) (Cat. #AP1126a) western blot analysis in mouse heart,skeletal muscle and rat heart,skeletal muscle tissue lysates (35ug/lane).This demonstrates the PLM antibody detected the PLM protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9Z239
Other Accession O08589
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 56188
Other Names Phospholemman, FXYD domain-containing ion transport regulator 1, Fxyd1, Plm
Target/Specificity This Mouse PLM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of mouse PLM.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse PLM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Fxyd1 {ECO:0000312|MGI:MGI:1889273}
Function Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:15563542, PubMed:18065526). Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (By similarity). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone (PubMed:19187398).
Cellular Location Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P56513}; Single-pass type I membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:O08589}; Single-pass type I membrane protein. Membrane, caveola {ECO:0000250|UniProtKB:O08589}. Cell membrane, sarcolemma, T- tubule {ECO:0000250|UniProtKB:O08589}. Note=Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t- tubules and intercalated disks. {ECO:0000250|UniProtKB:O08589}
Research Areas
Left ventricular function of isoproterenol-induced hypertrophied rat hearts perfused with blood: mechanical work and energetics.
Author : Nakajima-Takenaka C1, Zhang GX, Obata K, Tohne K, Matsuyoshi H, Nagai Y, Nishiyama A, Takaki M.
Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1736-43. doi: 10.1152/ajpheart.00672.2009. Epub 2009 Sep 4.
19734357

BACKGROUND

This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternative splicing of this gene results in multiple transcript variants which encode the same protein.

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