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DUOX2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - DUOX2 Antibody (Center) AP11227c
    DUOX2 Antibody (Center) (Cat. #AP11227c) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the DUOX2 antibody detected the DUOX2 protein (arrow).
  • 4 - DUOX2 Antibody (Center) AP11227c
    DUOX2 Antibody (Center) (Cat. #AP11227c) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, FC, E
Primary Accession Q9NRD8
Other Accession NP_054799
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 175364 Da
Additional info
Gene ID 50506
Other Names Dual oxidase 2, 1111-, Large NOX 2, Long NOX 2, NADH/NADPH thyroid oxidase p138-tox, NADPH oxidase/peroxidase DUOX2, NADPH thyroid oxidase 2, Thyroid oxidase 2, p138 thyroid oxidase, DUOX2, LNOX2, THOX2
Target/Specificity This DUOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 513-542 amino acids from the Central region of human DUOX2.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDUOX2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUOX2
Synonyms LNOX2, THOX2
Function Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
Cellular Location Apical cell membrane; Multi- pass membrane protein. Cell junction. Note=Localizes to the apical membrane of epithelial cells. Localizes on internal membrane structures under resting conditions, translocates to the plasma membrane and cell-cell junctions upon challenge with enteric pathogens, such as Escherichia coli
Tissue Location Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level) Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum and testis
Research Areas
Inducible Lung Epithelial Resistance Requires Multisource Reactive Oxygen Species Generation To Protect against Viral Infections.
Author : Kirkpatrick CT#1,Wang Y#1,Leiva Juarez MM1,Shivshankar P1,Pantaleón García J2,Plumer AK3,Kulkarni VV1,Ware HH1,Gulraiz F1,Chavez Cavasos MA1,Martinez Zayes G2,Wali S3,Rice AP4,Liu H4,Tour JM5,Sikkema WKA5,Cruz Solbes AS6,Youker KA6,Tuvim MJ1,Dickey BF1,3,
MBio. 2018 May 15;9(3). pii: e00696-18. doi: 10.1128/mBio.00696-18.
29764948

BACKGROUND

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain.

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Salmeen, A., et al. Oncogene 29(31):4473-4484(2010)
Linderholm, A.L., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 299 (2), L215-L221 (2010) :
Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)
Hill, T. III, et al. Biochem. Biophys. Res. Commun. 395(2):270-274(2010)

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