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IRF2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - IRF2 Antibody (Center) AP11225C
    Anti-IRF2 Antibody (Center) at 1:1000 dilution + LNCaP whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 39 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - IRF2 Antibody (Center) AP11225C
    IRF2 Antibody (Center) (Cat. #AP11225c) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the IRF2 antibody detected the IRF2 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P14316
Other Accession NP_002190
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 39354 Da
Additional info
Gene ID 3660
Other Names Interferon regulatory factor 2, IRF-2, IRF2
Target/Specificity This IRF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-255 amino acids from the Central region of human IRF2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIRF2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRF2
Function Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Cellular Location Nucleus.
Tissue Location Expressed throughout the epithelium of the colon. Also expressed in lamina propria
Research Areas
Embryonic stem cell-specific microRNAs contribute to pluripotency by inhibiting regulators of multiple differentiation pathways.
Author : Gruber AJ1, Grandy WA1, Balwierz PJ1, Dimitrova YA1, Pachkov M1, Ciaudo C2, Nimwegen Ev1, Zavolan M3.
Nucleic Acids Res. 2014 Oct 1;42(14):9313-26. doi: 10.1093/nar/gku544. Epub 2014 Jul 16.
25030899

BACKGROUND

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq].

REFERENCES

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lace, M.J., et al. Virology 399(2):270-279(2010)
Masumi, A., et al. Biochem. Biophys. Res. Commun. 391(4):1623-1628(2010)
Daley, D., et al. Hum. Genet. 125(4):445-459(2009)
Dhar, D., et al. PLoS ONE 4 (9), E7049 (2009) :

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