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GPX3 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - GPX3 Antibody (Center) AP11221c
    Western blot analysis of lysates from human kidney, plasma, mouse kidney, plasma and rat kidney tissue lysate(from left to right), using GPX3 Antibody (Center)(Cat. #AP11221c). AP11221c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
  • 1 - GPX3 Antibody (Center) AP11221c
    GPX3 Antibody (Center) (Cat. #AP11221c) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the GPX3 antibody detected the GPX3 protein (arrow).
  • 14 - GPX3 Antibody (Center) AP11221c
    GPX3 Antibody (Center) (Cat. #AP11221c)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GPX3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession P22352
Other Accession NP_002075
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 2878
Other Names Glutathione peroxidase 3, GPx-3, GSHPx-3, Extracellular glutathione peroxidase, Plasma glutathione peroxidase, GPx-P, GSHPx-P, GPX3, GPXP
Target/Specificity This GPX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-123 amino acids from the Central region of human GPX3.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGPX3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPX3
Synonyms GPXP
Function Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Cellular Location Secreted.
Tissue Location Secreted in plasma.
Research Areas
Silencing GPX3 Expression Promotes Tumor Metastasis in Human Thyroid Cancer.
Author : Zhao H, Li J, Li X, Han C, Zhang Y, Zheng L1, Guo M.
Curr Protein Pept Sci. 2015;16(4):316-21.
25929866

BACKGROUND

This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.

REFERENCES

Wang, J.Y., et al. Clin. Chim. Acta 411 (19-20), 1432-1436 (2010) : Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Fullerton, J.M., et al. Bipolar Disord 12(5):550-556(2010) Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010) Mistry, H.D., et al. Placenta 31(5):401-408(2010)

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