FBXO18 Antibody (C-term)
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application ![]()
| WB, E |
---|---|
Primary Accession | Q8NFZ0 |
Other Accession | NP_835363 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit Ig |
Gene ID | 84893 |
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Other Names | F-box only protein 18, F-box DNA helicase 1, FBXO18, FBH1, FBX18 |
Target/Specificity | This FBXO18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 741-769 amino acids from the C-terminal region of human FBXO18. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | FBXO18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FBXO18 |
---|---|
Synonyms | FBH1, FBX18 |
Function | DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction. |
Cellular Location | Nucleus. |
BACKGROUND
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
REFERENCES
Turnbull, C., et al. Nat. Genet. 42(6):504-507(2010)
Fugger, K., et al. J. Cell Biol. 186(5):655-663(2009)
Chiolo, I., et al. Mol. Cell. Biol. 27(21):7439-7450(2007)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Deloukas, P., et al. Nature 429(6990):375-381(2004)

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