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CCNG1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CCNG1 Antibody (C-term) AP11209b
    CCNG1 Antibody (C-term) (Cat. #AP11209b) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CCNG1 antibody detected the CCNG1 protein (arrow).
  • 4 - CCNG1 Antibody (C-term) AP11209b
    CCNG1 Antibody (C-term) (Cat. #AP11209b) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, FC, E
Primary Accession P51959
Other Accession Q52QT8, NP_004051
Reactivity Mouse
Predicted Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 34074 Da
Additional info
Gene ID 900
Other Names Cyclin-G1, Cyclin-G, CCNG1, CCNG, CYCG1
Target/Specificity This CCNG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 amino acids from the C-terminal region of human CCNG1.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCNG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCNG1
Synonyms CCNG, CYCG1
Function May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).
Cellular Location Nucleus. Note=DNA replication foci after DNA damage
Tissue Location High levels in skeletal muscle, ovary, kidney and colon
Research Areas
MicroRNA-9 inhibition of cell proliferation and identification of novel miR-9 targets by transcriptome profiling in breast cancer cells.
Author : Selcuklu SD1, Donoghue MT, Rehmet K, de Souza Gomes M, Fort A, Kovvuru P, Muniyappa MK, Kerin MJ, Enright AJ, Spillane C.
J Biol Chem. 2012 Aug 24;287(35):29516-28. doi: 10.1074/jbc.M111.335943. Epub 2012 Jul 2.
22761433

BACKGROUND

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq].

REFERENCES

Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009) Fornari, F., et al. Cancer Res. 69(14):5761-5767(2009) Li, H., et al. Mol. Cell. Biol. 29(3):919-928(2009) Piscopo, D.M., et al. Cancer Res. 68(14):5581-5590(2008) Seo, H.R., et al. J. Biol. Chem. 283(23):15601-15610(2008)

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