|Application ||WB, E|
|Other Names||Galectin-1, Gal-1, 14 kDa laminin-binding protein, HLBP14, 14 kDa lectin, Beta-galactoside-binding lectin L-14-I, Galaptin, HBL, HPL, Lactose-binding lectin 1, Lectin galactoside-binding soluble 1, Putative MAPK-activating protein PM12, S-Lac lectin 1, LGALS1|
|Target/Specificity||This GLT Antibody is generated from rabbits immunized with Gst fusion protein from human GLT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Galectin-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level) Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells|
Provided below are standard protocols that you may find useful for product applications.
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq].
Okano, K., et al. Exp. Cell Res. 316(19):3282-3291(2010) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Pal, Z., et al. J. Neuroimmunol. (2010) In press : Tang, C.E., et al. Oncol. Rep. 24(2):495-500(2010) Garner, O.B., et al. PLoS Pathog. 6 (7), E1000993 (2010) :