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>   首页   >   产品   >   一抗   >   细胞生物学   >   KTAP2 Antibody (C-term)   

KTAP2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - KTAP2 Antibody  (C-term) AP11178b
    KTAP2 Antibody (C-term) (Cat. #AP11178b) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the KTAP2 antibody detected the KTAP2 protein (arrow).
  • 1 - KTAP2 Antibody  (C-term) AP11178b
    KTAP2 Antibody (C-term) (Cat. #AP11178b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the KTAP2 antibody detected the KTAP2 protein (arrow).
  • 14 - KTAP2 Antibody  (C-term) AP11178b
    KTAP2 Antibody (C-term) (Cat. #AP11178b)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KTAP2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q8N6L1
Other Accession B2RZC9, NP_776251.1
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 14679 Da
Additional info
Gene ID 200185
Other Names Keratinocyte-associated protein 2, KCP-2, KRTCAP2, KCP2
Target/Specificity This KTAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-162 amino acids from the C-terminal region of human KTAP2.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKTAP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRTCAP2
Synonyms KCP2
Function Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:22467853). May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1 (PubMed:21768116).
Cellular Location Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Expressed in skin, heart, placental, liver, skeletal muscle, kidney, pancreas, keratinocytes and dermal fibroblasts.
Research Areas

BACKGROUND

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.

REFERENCES

Shibatani, T., et al. Biochemistry 44(16):5982-5992(2005)
Bonkobara, M., et al. Br. J. Dermatol. 148(4):654-664(2003)

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