|Application ||WB, IHC-P, E|
|Other Accession||NP_733764.1, NP_001155155.1|
|Calculated MW||128533 Da|
|Other Names||Otoancorin, OTOA|
|Target/Specificity||This OTOA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-120 amino acids from the N-terminal region of human OTOA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OTOA Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as an adhesion molecule.|
|Cellular Location||Apical cell membrane; Lipid- anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix. Note=At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes.|
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Shahin, H., et al. Eur. J. Hum. Genet. 18(4):407-413(2010)
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Hofmann, O., et al. Proc. Natl. Acad. Sci. U.S.A. 105(51):20422-20427(2008)
Zwaenepoel, I., et al. Proc. Natl. Acad. Sci. U.S.A. 99(9):6240-6245(2002)