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HBO1/MYST2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - HBO1/MYST2 Antibody (Center) AP1113c
    HBO1/MYST2 Antibody (Center) (Cat. #AP1113c) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the HBO1/MYST2 antibody detected the HBO1/MYST2 protein (arrow).
  • 14 - HBO1/MYST2 Antibody (Center) AP1113c
    Formalin-fixed and paraffin-embedded human testis tissue reacted with HBO1/MYST2 antibody (Center) (Cat.#AP1113c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • 3 - HBO1/MYST2 Antibody (Center) AP1113c
    Fluorescent confocal image of Hela cell stained with HBO1/MYST2 Antibody (Center)(Cat#AP1113c). Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with HBO1/MYST2 primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃). Nuclei were counterstained with DAPI (blue) (10 µg/ml, 10 min). HBO1/MYST2 immunoreactivity is localized to nucleus significantly.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IF, IHC-P, E
Primary Accession O95251
Other Accession Q810T5, Q5SVQ0
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 11143
Other Names Histone acetyltransferase KAT7, Histone acetyltransferase binding to ORC1, Lysine acetyltransferase 7, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2, MYST-2, KAT7, HBO1, HBOa, MYST2
Target/Specificity This HBO1/MYST2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-246 amino acids from the Central region of human HBO1/MYST2.
Dilution WB~~1:1000
IHC-P~~1:10~50
IF~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHBO1/MYST2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KAT7
Synonyms HBO1, HBOa, MYST2
Function Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.
Cellular Location Nucleus, nucleoplasm
Tissue Location Ubiquitously expressed, with highest levels in testis.
Research Areas

BACKGROUND

HBO1/MYST2 is a histone acetyltransferase which specifically represses AR-mediated transcription. It may play a role in DNA replication.

REFERENCES

Wu,Z.Q., Proc. Natl. Acad. Sci. U.S.A. 105 (6), 1919-1924 (2008)
Iizuka,M., Mol. Cell. Biol. 28 (1), 140-153 (2008)

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