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CUZD1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - CUZD1 Antibody (C-term) AP11139b
    CUZD1 Antibody (C-term) (Cat. #AP11139b) western blot analysis in human normal uterus tissue lysates (35ug/lane).This demonstrates the CUZD1 antibody detected the CUZD1 protein (arrow).
  • 14 - CUZD1 Antibody (C-term) AP11139b
    CUZD1 Antibody (C-term) (Cat. #AP11139b)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancrease tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CUZD1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 3 - CUZD1 Antibody (C-term) AP11139b
    Confocal immunofluorescent analysis of CUZD1 Antibody (C-term)(Cat#AP11139b) with 293 cell followed by Alexa Fluor? 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, IF, E
Primary Accession Q86UP6
Other Accession NP_071317.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 68153 Da
Additional info
Gene ID 50624
Other Names CUB and zona pellucida-like domain-containing protein 1, CUB and ZP domain-containing protein 1, Transmembrane protein UO-44, CUZD1 {ECO:0000312|EMBL:CAH700061}
Target/Specificity This CUZD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 579-607 amino acids from the C-terminal region of human CUZD1.
Dilution WB~~1:1000
IHC-P~~1:10~50
IF~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCUZD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CUZD1 {ECO:0000312|EMBL:CAH70006.1}
Function CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.
Cellular Location Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein. Note=Associated with zymogen granule membranes
Tissue Location Detected in pancreas and epithelium of ovary. Expressed at higher levels in ovarian tumors than in normal tissue.
Research Areas

BACKGROUND

Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.

REFERENCES

Leong, C.T., et al. Oncogene 26(6):870-880(2007) Blanchetot, C., et al. Methods 35(1):44-53(2005) Leong, C.T., et al. Oncogene 23(33):5707-5718(2004) Deloukas, P., et al. Nature 429(6990):375-381(2004) Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)

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