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IFT88 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - IFT88 Antibody (C-term) AP11138b
    IFT88 Antibody (C-term) (Cat. #AP11138b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the IFT88 antibody detected the IFT88 protein (arrow).
  • 1 - IFT88 Antibody (C-term) AP11138b
    IFT88 Antibody (C-term) (Cat. #AP11138b) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the IFT88 antibody detected the IFT88 protein (arrow).
  • 14 - IFT88 Antibody (C-term) AP11138b
    IFT88 Antibody (C-term) (Cat. #AP11138b)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IFT88 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 3 - IFT88 Antibody (C-term) AP11138b
    Confocal immunofluorescent analysis of IFT88 Antibody (C-term)(Cat#AP11138b) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, IF, E
Primary Accession Q13099
Other Accession Q61371, NP_006522.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 94270 Da
Additional info
Gene ID 8100
Other Names Intraflagellar transport protein 88 homolog, Recessive polycystic kidney disease protein Tg737 homolog, Tetratricopeptide repeat protein 10, TPR repeat protein 10, IFT88, TG737, TTC10
Target/Specificity This IFT88 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 791-820 amino acids from the C-terminal region of human IFT88.
Dilution WB~~1:1000
IHC-P~~1:10~50
IF~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIFT88 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IFT88
Synonyms TG737, TTC10
Function Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body
Tissue Location Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas
Research Areas
Basic fibroblast growth factor increases IFT88 expression in chondrocytes.
Author : Zhan D1,Xiang W2,Guo F2,Ma Y1.
Mol Med Rep. 2017 Sep 8. doi: 10.3892/mmr.2017.7449. [Epub ahead of print]
28901443
HDAC6 inhibition suppresses chondrosarcoma by restoring the expression of primary cilia.
Author : Xiang W1,Guo F1,Cheng W2,Zhang J1,Huang J1,Wang R1,Ma Z3,Xu K1.
Oncol Rep. 2017 Jun 2. doi: 10.3892/or.2017.5694. [Epub ahead of print]
28586053

BACKGROUND

This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq].

REFERENCES

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Robert, A., et al. J. Cell. Sci. 120 (PT 4), 628-637 (2007) :
Khanna, H., et al. J. Biol. Chem. 280(39):33580-33587(2005)
Lehner, B., et al. Genomics 83(1):153-167(2004)
Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)

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