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ELP3 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ELP3 Antibody (N-term) AP1112a
    Western blot analysis of ELP3(arrow) using rabbit polyclonal ELP3 Antibody (N-term) (Cat.#AP1112a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ELP3 gene (Lane 2) (Origene Technologies).
  • 1 - ELP3 Antibody (N-term) AP1112a
    ELP3 Antibody (N-term) (Cat.#AP1112a) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the ELP3 antibody detected the ELP3 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9H9T3
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 62259 Da
Additional info
Gene ID 55140
Other Names Elongator complex protein 3, hELP3, ELP3
Target/Specificity This ELP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-44 amino acids from the N-terminal region of human ELP3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsELP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ELP3
Function Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin (PubMed:19185337). May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha- tubulin acetylation (By similarity).
Cellular Location Cytoplasm. Isoform 2: Cytoplasm. Nucleus.
Tissue Location Expressed in the cerebellum and spinal motor neurons.
Research Areas
ELP3 localises to mitochondria and actin-rich domains at edges of HeLa cells.
Author : Barton D, Braet F, Marc J, Overall R, Gardiner J.
Neurosci Lett. 2009 May 8;455(1):60-4. doi: 10.1016/j.neulet.2009.03.006. Epub 2009 Mar 6.
19429107

BACKGROUND

Elongator complex protein 3 (ELP3) is a catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. It may also have a methyltransferase activity.

REFERENCES

Han,Q., Acta Biochim. Biophys. Sin. (Shanghai) 39 (6), 453-461 (2007)
Kim,J.H., Proc. Natl. Acad. Sci. U.S.A. 99 (3), 1241-1246 (2002)
Ninomiya,Y., J. Biochem. 118 (2), 380-389 (1995)

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