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>   首页   >   产品   >   一抗   >   干细胞   >   HDAC11 Antibody (C-term)   

HDAC11 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - HDAC11 Antibody (C-term) AP1111b
    The anti-HDAC11 Pab (Cat. #AP1111b) is used in Western blot to detect HDAC11 in mouse brain tissue lysate.
  • 14 - HDAC11 Antibody (C-term) AP1111b
    Formalin-fixed and paraffin-embedded human testicle tumor tissue reacted with HDAC11 antibody (C-term)(Cat.#AP1111b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q96DB2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 79885
Other Names Histone deacetylase 11, HD11, HDAC11
Target/Specificity This HDAC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 313-345 amino acids from the C-terminal region of human HDAC11.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHDAC11 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HDAC11
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Cellular Location Nucleus. Note=Predominantly nuclear.
Tissue Location Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis
Research Areas
The functional interactome landscape of the human histone deacetylase family.
Author : Joshi P1, Greco TM, Guise AJ, Luo Y, Yu F, Nesvizhskii AI, Cristea IM.
Mol Syst Biol. 2013;9:672. doi: 10.1038/msb.2013.26.
23752268
A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression.
Author : Keedy KS, Archin NM, Gates AT, Espeseth A, Hazuda DJ, Margolis DM.
J Virol. 2009 May;83(10):4749-56. doi: 10.1128/JVI.02585-08. Epub 2009 Mar 11.
19279091

BACKGROUND

HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.

REFERENCES

Keedy, K.S. et al. J Virol. May; 83(10): 4749?756(2009).
Voelter-Mahlknecht S, et al., Int J Mol Med. 2005 Oct;16(4):589-98.
Bradbury CA, et al., Leukemia. 2005 Oct;19(10):1751-9.
Gregoretti IV, et al., J Mol Biol. 2004 Apr 16;338(1):17-31.
Gao, L., et al., J. Biol. Chem. 277(28):25748-25755 (2002).

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