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DFNB31 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - DFNB31 Antibody (Center) AP11113c
    Western blot analysis of lysate from human kidney tissue lysate, using DFNB31 Antibody (Center)(Cat. #AP11113c). AP11113c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.
  • 14 - DFNB31 Antibody (Center) AP11113c
    DFNB31 Antibody (Center) (Cat. #AP11113c)immunohistochemistry analysis in formalin fixed and paraffin embedded stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DFNB31 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q9P202
Other Accession NP_056219.3, NP_001077354.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 96586 Da
Additional info
Gene ID 25861
Other Names Whirlin, Autosomal recessive deafness type 31 protein, DFNB31, KIAA1526, WHRN
Target/Specificity This DFNB31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 378-406 amino acids from the Central region of human DFNB31.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDFNB31 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DFNB31
Synonyms KIAA1526, WHRN
Function Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear.
Cellular Location Cytoplasm. Cell projection, stereocilium. Cell projection, growth cone. Note=Detected at the level of stereocilia in inner outer hair cells of the cochlea and vestibule. Colocalizes with the growing ends of actin filaments (By similarity). Colocalizes with MPP1 in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC). {ECO:0000250, ECO:0000269|PubMed:17584769}
Research Areas

BACKGROUND

This gene is thought to function in the organization and stabilization of sterocilia elongation and actin cystoskeletal assembly, based on studies of the related mouse gene. Mutations in this gene have been associated with autosomal recessive non-syndromic deafness and Usher Syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

REFERENCES

Letra, A., et al. Am. J. Med. Genet. A 152A (7), 1701-1710 (2010) :
Secolin, R., et al. Psychiatr. Genet. 20(3):126-129(2010)
Aller, E., et al. Mol. Vis. 16, 495-500 (2010) :
Toiyama, Y., et al. Int. J. Oncol. 35(4):709-715(2009)
Gosens, I., et al. Hum. Mol. Genet. 16(16):1993-2003(2007)

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