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>   首页   >   产品   >   一抗   >   细胞生物学   >   HIP1R Antibody (N-term)   

HIP1R Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - HIP1R Antibody (N-term) AP11109a
    HIP1R Antibody (N-term) (Cat. #AP11109a) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the HIP1R antibody detected the HIP1R protein (arrow).
  • 14 - HIP1R Antibody (N-term) AP11109a
    HIP1R Antibody (N-term) (Cat. #AP11109a)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HIP1R Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 4 - HIP1R Antibody (N-term) AP11109a
    HIP1R Antibody (N-term) (Cat. #AP11109a) flow cytometric analysis of Ramos cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, FC, E
Primary Accession O75146
Other Accession NP_003950.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 119388 Da
Additional info
Gene ID 9026
Other Names Huntingtin-interacting protein 1-related protein, HIP1-related protein, Huntingtin-interacting protein 12, HIP-12, HIP1R, HIP12, KIAA0655
Target/Specificity This HIP1R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the N-terminal region of human HIP1R.
Dilution WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHIP1R Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HIP1R
Synonyms HIP12, KIAA0655
Function Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Cellular Location Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region
Tissue Location Brain, heart, kidney, pancreas, and liver, but not in lung or placenta
Research Areas

BACKGROUND

This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).

REFERENCES

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Kim, J.H., et al. Cell. Physiol. Biochem. 23 (1-3), 43-52 (2009) :
Wilbur, J.D., et al. J. Biol. Chem. 283(47):32870-32879(2008)
Poupon, V., et al. Proc. Natl. Acad. Sci. U.S.A. 105(1):168-173(2008)
Parker, J.A., et al. J. Neurosci. 27(41):11056-11064(2007)

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