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BTF3 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - BTF3 Antibody (N-term) AP11100a
    BTF3 Antibody (N-term) (Cat. #AP11100a) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the BTF3 antibody detected the BTF3 protein (arrow).
  • 1 - BTF3 Antibody (N-term) AP11100a
    BTF3 Antibody (N-term) (Cat. #AP11100a) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the BTF3 antibody detected the BTF3 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P20290
Other Accession NP_001198.2, NP_001032726.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 22168 Da
Additional info
Gene ID 689
Other Names Transcription factor BTF3, Nascent polypeptide-associated complex subunit beta, NAC-beta, RNA polymerase B transcription factor 3, BTF3, NACB
Target/Specificity This BTF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BTF3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBTF3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BTF3
Synonyms NACB
Function When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.
Cellular Location Cytoplasm. Nucleus. Note=The heterodimer with NACA is cytoplasmic
Research Areas

BACKGROUND

This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes.

REFERENCES

Green, C.D., et al. Mol. Cancer Res. 5(11):1191-1200(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Kusumawidjaja, G., et al. Cancer Biol. Ther. 6(3):367-376(2007)
Freire, M.A. Gene 345(2):271-277(2005)
Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)

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