- 文献引用 : 1
|Application ||WB, IHC-P, E|
|Calculated MW||40176 Da|
|Other Names||Guanine nucleotide-binding protein G(t) subunit alpha-2, Transducin alpha-2 chain, GNAT2, GNATC|
|Target/Specificity||This GNAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-169 amino acids from the Central region of human GNAT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GNAT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.|
|Tissue Location||Retinal rod outer segment.|
Author : Liszt KI1,2,Ley JP3,Lieder B1,2,Behrens M4,Stöger V2,Reiner A5,Hochkogler CM2,Köck E1,Marchiori A4,Hans J3,Widder S3,Krammer G3,Sanger GJ6,Somoza MM7,Meyerhof W4,Somoza V8,2.
Proc Natl Acad Sci U S A. 2017 Jul 10. pii: 201703728. doi: 10.1073/pnas.1703728114. [Epub ahead of print]
Provided below are standard protocols that you may find useful for product applications.
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones.
Shi, J., et al. Mol. Psychiatry (2010) In press :
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Oldham, W.M., et al. Nat. Struct. Mol. Biol. 13(9):772-777(2006)
Rosenberg, T., et al. Invest. Ophthalmol. Vis. Sci. 45(12):4256-4262(2004)