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ZC3H3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ZC3H3 Antibody (C-term) AP11020b
    ZC3H3 Antibody (C-term) (Cat. #AP11020b) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the ZC3H3 antibody detected the ZC3H3 protein (arrow).
  • 14 - ZC3H3 Antibody (C-term) AP11020b
    ZC3H3 Antibody (C-term) (Cat. #AP11020b) immunohistochemistry analysis in formalin fixed and paraffin embedded human skin carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ZC3H3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q8IXZ2
Other Accession Q8CHP0, NP_055932.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 101941 Da
Additional info
Gene ID 23144
Other Names Zinc finger CCCH domain-containing protein 3, ZC3H3, KIAA0150, ZC3HDC3
Target/Specificity This ZC3H3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 920-948 amino acids from the C-terminal region of human ZC3H3.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZC3H3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZC3H3
Function Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double- stranded DNA in vitro. Involved in RNA cleavage (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q8CHP0}.
Research Areas

BACKGROUND

Contains 5 C3H1 type zinc fingers.

REFERENCES

Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Hurt, J.A., et al. J. Cell Biol. 185(2):265-277(2009)

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