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GDPD5 Antibody (center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - GDPD5 Antibody (center) AP10992c
    GDPD5 Antibody (center) (Cat. #AP10992c) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the GDPD5 antibody detected the GDPD5 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q8WTR4
Other Accession NP_110419.5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 68586 Da
Additional info
Gene ID 81544
Other Names Glycerophosphodiester phosphodiesterase domain-containing protein 5, 31--, Glycerophosphodiester phosphodiesterase 2, GDPD5, GDE2
Target/Specificity This GDPD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 342-369 amino acids from the Central region of human GDPD5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGDPD5 Antibody (center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GDPD5
Synonyms GDE2
Function Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (By similarity). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine (By similarity).
Cellular Location Endomembrane system {ECO:0000250|UniProtKB:Q640M6}; Multi-pass membrane protein. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q640M6}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q640M6}. Note=In a punctate perinuclear pattern. {ECO:0000250|UniProtKB:Q640M6}
Research Areas
Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer.
Author : Cao MD, Döpkens M, Krishnamachary B, Vesuna F, Gadiya MM, Lønning PE, Bhujwalla ZM, Gribbestad IS, Glunde K.
NMR Biomed. 2012 Sep;25(9):1033-42. doi: 10.1002/nbm.2766. Epub 2012 Jan 26.
22279038

BACKGROUND

Glycerophosphodiester phosphodiesterases (GDPDs; EC 3.1.4.46), such as GDPD5, are involved in glycerol metabolism (Lang et al., 2008 [PubMed 17578682]).

REFERENCES

Lang, Q., et al. Mol. Biol. Rep. 35(3):351-359(2008) Rao, M., et al. Science 309(5744):2212-2215(2005) Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004) Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)

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