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ZC12A Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ZC12A Antibody (Center) AP10978c
    ZC12A Antibody (Center) (Cat. #AP10978c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ZC12A antibody detected the ZC12A protein (arrow).
  • 14 - ZC12A Antibody (Center) AP10978c
    ZC12A antibody (Center) (Cat. #AP10978c) immunohistochemistry analysis in formalin fixed and paraffin embedded human spleen tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ZC12A antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 4 - ZC12A Antibody (Center) AP10978c
    ZC12A Antibody (Center) (Cat. #AP10978c) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, FC, E
Primary Accession Q5D1E8
Other Accession NP_079355.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 65699 Da
Additional info
Gene ID 80149
Other Names Ribonuclease ZC3H12A, 31--, MCP-induced protein 1, Zinc finger CCCH domain-containing protein 12A, ZC3H12A {ECO:0000312|EMBL:EAX073461}
Target/Specificity This ZC12A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-358 amino acids from the Central region of human ZC12A.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZC12A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZC3H12A {ECO:0000312|EMBL:EAX07346.1}
Function Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA (By similarity). Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19.
Cellular Location Cytoplasm. Nucleus
Research Areas

BACKGROUND

ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.

REFERENCES

Skalniak, L., et al. FEBS J. 276(20):5892-5905(2009)
Vrotsos, E.G., et al. Brain Res. Bull. 79(2):97-103(2009)
Niu, J., et al. J. Biol. Chem. 283(21):14542-14551(2008)
Liang, J., et al. J. Biol. Chem. 283(10):6337-6346(2008)
Zhou, L., et al. Circ. Res. 98(9):1177-1185(2006)

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