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FOSL2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - FOSL2 Antibody (Center) AP10972C
    Western blot analysis of lysate from Daudi cell line, using FOSL2 Antibody (Center)(Cat. #AP10972c). AP10972c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
  • 1 - FOSL2 Antibody (Center) AP10972C
    FOSL2 Antibody (Center) (Cat. #AP10972c) western blot analysis in CHO cell line lysates (35ug/lane).This demonstrates the FOSL2 antibody detected the FOSL2 protein (arrow).
  • 14 - FOSL2 Antibody (Center) AP10972C
    FOSL2 antibody (Center) (Cat. #AP10972c) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the FOSL2 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession P15408
Other Accession P51145, P47930, P18625, NP_005244.1
Reactivity Human, Hamster
Predicted Chicken, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 35193 Da
Additional info
Gene ID 2355
Other Names Fos-related antigen 2, FRA-2, FOSL2, FRA2
Target/Specificity This FOSL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-122 amino acids from the Central region of human FOSL2.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFOSL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOSL2
Synonyms FRA2
Function Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.
Cellular Location Nucleus.
Research Areas

BACKGROUND

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.

REFERENCES

Bozec, A., et al. J. Cell Biol. 190(6):1093-1106(2010)
Bolat, I., et al. Folia Histochem. Cytobiol. 48(2):197-201(2010)
Reich, N., et al. Arthritis Rheum. 62(1):280-290(2010)
Maurer, B., et al. Circulation 120(23):2367-2376(2009)
Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :

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