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BCORL1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - BCORL1 Antibody (N-term) AP10847a
    BCORL1 Antibody (N-term) (Cat. #AP10847a) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the BCORL1 antibody detected the BCORL1 protein (arrow).
  • 14 - BCORL1 Antibody (N-term) AP10847a
    BCORL1 antibody (N-term) (Cat. #AP10847a) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the BCORL1 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 4 - BCORL1 Antibody (N-term) AP10847a
    BCORL1 Antibody (N-term) (Cat. #AP10847a) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, FC, E
Primary Accession Q5H9F3
Other Accession NP_068765.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 182526 Da
Additional info
Gene ID 63035
Other Names BCL-6 corepressor-like protein 1, BCoR-L1, BCoR-like protein 1, BCORL1
Target/Specificity This BCORL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-98 amino acids from the N-terminal region of human BCORL1.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBCORL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCORL1
Function Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.
Cellular Location Nucleus.
Tissue Location Detected in testis and prostate. Detected at lower levels in peripheral blood leukocytes and spleen
Research Areas

BACKGROUND

The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene.

REFERENCES

Pagan, J.K., et al. J. Biol. Chem. 282(20):15248-15257(2007)
Lose, F., et al. Breast Cancer Res. 9 (4), R54 (2007) :

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