|Application ||WB, IHC-P, FC, E|
|Calculated MW||182526 Da|
|Other Names||BCL-6 corepressor-like protein 1, BCoR-L1, BCoR-like protein 1, BCORL1|
|Target/Specificity||This BCORL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-98 amino acids from the N-terminal region of human BCORL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BCORL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor.|
|Tissue Location||Detected in testis and prostate. Detected at lower levels in peripheral blood leukocytes and spleen|
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene.
Pagan, J.K., et al. J. Biol. Chem. 282(20):15248-15257(2007)
Lose, F., et al. Breast Cancer Res. 9 (4), R54 (2007) :