|Application ||WB, E|
|Other Accession||Q9CQU8, NP_659418.1|
|Calculated MW||18504 Da|
|Other Names||Mitochondrial inner membrane protease subunit 1, 3421-, IMP1-like protein, IMMP1L|
|Target/Specificity||This IMMP1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-127 amino acids from the C-terminal region of human IMMP1L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IMMP1L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|
|Cellular Location||Mitochondrion inner membrane|
Provided below are standard protocols that you may find useful for product applications.
The mitochondrial inner membrane peptidase (IMP) complex generates mature, active proteins in the mitochondrial intermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins. IMP1 and IMP2 (IMMP2L; MIM 605977) are the catalytic subunits of the IMP complex (Burri et al., 2005 [PubMed 15814844]).
Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Taylor, T.D., et al. Nature 440(7083):497-500(2006)
Burri, L., et al. Mol. Biol. Cell 16(6):2926-2933(2005)