|Application ||WB, FC, E|
|Other Accession||Q4VBD2, Q5ZLG8, NP_699196.2|
|Calculated MW||64260 Da|
|Other Names||Transmembrane anterior posterior transformation protein 1 homolog, Cytomegalovirus partial fusion receptor, TAPT1, CMVFR|
|Target/Specificity||This TAPT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 530-558 amino acids from the C-terminal region of human TAPT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAPT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in primary cilia formation (PubMed:26365339). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium basal body. Membrane; Multi-pass membrane protein|
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a highly conserved, putative transmembrane protein. A mutation in the mouse ortholog of this gene results in homeotic, posterior-to-anterior transformations of the axial skeleton which are similar to the phenotype of mouse homeobox C8 gene mutants. This gene is proposed to function downstream of homeobox C8 to transduce extracellular patterning information during axial skeleton development. An alternatively spliced transcript variant encoding a substantially different isoform has been described, but its biological validity has not been determined.
Howell, G.R., et al. Genetics 175(2):699-707(2007)
Baldwin, B.R., et al. J. Gen. Virol. 81 (PT 1), 27-35 (2000) :
Baldwin, B.R., et al. Biochem. Biophys. Res. Commun. 219(2):668-673(1996)