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KAT5 / Tip60/HTATIP Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - KAT5 / Tip60/HTATIP Antibody (N-term) AP1081a
    Western blot analysis of anti-HTATIP Pab(Cat. #AP1081a) in mouse liver tissue lysate (35ug/lane). HTATIP(arrow) was detected using the purified Pab.
  • 1 - KAT5 / Tip60/HTATIP Antibody (N-term) AP1081a
    Western blot analysis of anti-HTATIP Pab (Cat. #AP1081a) in Jurkat cell line lysates (35ug/lane). HTATIP(arrow) was detected using the purified Pab.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q92993
Other Accession Q99MK2, Q8CHK4
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 58582 Da
Additional info
Gene ID 10524
Other Names Histone acetyltransferase KAT5, 60 kDa Tat-interactive protein, Tip60, Histone acetyltransferase HTATIP, HIV-1 Tat interactive protein, Lysine acetyltransferase 5, cPLA(2)-interacting protein, KAT5, HTATIP, TIP60
Target/Specificity This KAT5 / Tip60/HTATIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-64 amino acids from the N-terminal region of human KAT5 / Tip60/HTATIP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKAT5 / Tip60/HTATIP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KAT5
Synonyms HTATIP, TIP60
Function Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2.
Cellular Location Nucleus. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies
Research Areas
Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX.
Author : Yamagata K, Kitabayashi I.
Biochem Biophys Res Commun. 2009 Dec 25;390(4):1355-60. doi: 10.1016/j.bbrc.2009.10.156. Epub 2009 Nov 4.
19895790

BACKGROUND

HTATIP belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

REFERENCES

Cai, Y., et al., J. Biol. Chem. 280(14):13665-13670 (2005). Patel, J.H., et al., Mol. Cell. Biol. 24(24):10826-10834 (2004). Legube, G., et al., J. Biol. Chem. 279(43):44825-44833 (2004). Franzese, O., et al., Cell Death Differ. 11(7):782-784 (2004). Taubert, S., et al., Mol. Cell. Biol. 24(10):4546-4556 (2004).

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