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GCN5 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - GCN5 Antibody (N-term) AP1078d
    Western blot analysis of anti-GCN5 Antibody (N-term)(Cat.#AP1078d) in 293 cell line lysates (35ug/lane). GCN5(arrow) was detected using the purified Pab.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q92830
Other Accession Q9JHD2, Q8N1A2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 2648
Other Names Histone acetyltransferase KAT2A, General control of amino acid synthesis protein 5-like 2, Histone acetyltransferase GCN5, HsGCN5, Lysine acetyltransferase 2A, STAF97, KAT2A, GCN5, GCN5L2, HGCN5
Target/Specificity This GCN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-94 amino acids from the N-terminal region of human GCN5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGCN5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KAT2A
Synonyms GCN5, GCN5L2, HGCN5
Function Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Cellular Location Nucleus.
Tissue Location Expressed in all tissues tested, with most abundant expression in ovary
Research Areas

BACKGROUND

GCN5 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. This protein has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles.

REFERENCES

Sabo,A., Mol. Cell. Biol. 28 (7), 2201-2212 (2008)
Wiper-Bergeron,N., Proc. Natl. Acad. Sci. U.S.A. 104 (8), 2703-2708 (2007)
Oishi,H., J. Biol. Chem. 281 (1), 20-26 (2006)
Kikuchi,H., Gene 347 (1), 83-97 (2005)

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