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>   首页   >   产品   >   一抗   >   细胞生物学   >   CB086 Antibody (C-term)   

CB086 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CB086 Antibody  (C-term) AP10783b
    CB086 Antibody (C-term) (Cat. #AP10783b) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the CB086 antibody detected the CB086 protein (arrow).
  • 14 - CB086 Antibody  (C-term) AP10783b
    CB086 Antibody (C-term) (Cat. #AP10783b) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CB086 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession O95876
Other Accession NP_056994.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 85084 Da
Additional info
Gene ID 51057
Other Names WD repeat-containing and planar cell polarity effector protein fritz homolog, hFRTZ, Bardet-Biedl syndrome 15 protein, WD repeat-containing and planar cell polarity effector protein, WDPCP, BBS15, C2orf86, FRITZ
Target/Specificity This CB086 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 676-705 amino acids from the C-terminal region of human CB086.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCB086 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WDPCP
Synonyms BBS15, C2orf86, FRITZ
Function Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q32NR9}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q32NR9}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q32NR9}
Research Areas

BACKGROUND

The C2ORF86 gene encodes an ortholog of Drosophila 'fritz,' a cytoplasmic WD40 repeat protein that controls planar cell polarity (summarized by Kim et al., 2010 [PubMed 20671153]).

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kim, S.K., et al. Science 329(5997):1337-1340(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Eeles, R.A., et al. Nat. Genet. 41(10):1116-1121(2009)
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :

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