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RT4I1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - RT4I1 Antibody  (C-term) AP10774b
    RT4I1 Antibody (C-term) (Cat. #AP10774b) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the RT4I1 antibody detected the RT4I1 protein (arrow).
  • 14 - RT4I1 Antibody  (C-term) AP10774b
    RT4I1 Antibody (C-term) (Cat. #AP10774b) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the RT4I1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 4 - RT4I1 Antibody  (C-term) AP10774b
    RT4I1 Antibody (C-term) (Cat. #AP10774b) flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, FC, E
Primary Accession Q8WWV3
Other Accession NP_116119.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 43590 Da
Additional info
Gene ID 84816
Other Names Reticulon-4-interacting protein 1, mitochondrial, NOGO-interacting mitochondrial protein, RTN4IP1, NIMP
Target/Specificity This RT4I1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-363 amino acids from the C-terminal region of human RT4I1.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRT4I1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RTN4IP1
Synonyms NIMP
Function Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.
Cellular Location Mitochondrion outer membrane Note=Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria
Tissue Location Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta.
Research Areas

BACKGROUND

This gene encodes a novel mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. The interaction of reticulon 4 with mitochondrial proteins may provide insight into the mechanisms for reticulon-induced inhibition of neurite growth.

REFERENCES

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Domeniconi, M., et al. Neuron 35(2):283-290(2002)
Hu, W.H., et al. J. Neurochem. 81(1):36-45(2002)

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