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>   首页   >   产品   >   一抗   >   癌症   >   RNT2 Antibody (N-term)   

RNT2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - RNT2 Antibody (N-term) AP10764a
    Western blot analysis of lysates from 293T cell line, human brain tissue lysate (from left to right), using RNT2 Antibody (N-term)(Cat. #AP10764a). AP10764a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
  • 1 - RNT2 Antibody (N-term) AP10764a
    RNT2 Antibody (N-term) (Cat. #AP10764a) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RNT2 antibody detected the RNT2 protein (arrow).
  • 14 - RNT2 Antibody (N-term) AP10764a
    RNT2 antibody (N-term) (Cat. #AP10764a) immunohistochemistry analysis in formalin fixed and paraffin embedded human spleen carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the RNT2 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession O00584
Other Accession NP_003721.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 29481 Da
Additional info
Gene ID 8635
Other Names Ribonuclease T2, 3127-, Ribonuclease 6, RNASET2, RNASE6PL
Target/Specificity This RNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-36 amino acids from the N-terminal region of human RNT2.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRNT2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNASET2
Synonyms RNASE6PL
Function Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.
Cellular Location Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Note=Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction
Tissue Location Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain
Research Areas

BACKGROUND

This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement.

REFERENCES

Fransen, K., et al. Hum. Mol. Genet. 19(17):3482-3488(2010)
Quan, C., et al. Nat. Genet. 42(7):614-618(2010)
Liu, J., et al. J. Cell. Mol. Med. 14(5):1146-1155(2010)
Henneke, M., et al. Nat. Genet. 41(7):773-775(2009)
Monti, L., et al. Oncol. Res. 17(2):69-74(2008)

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