|Application ||WB, IHC-P, FC, E|
|Other Accession||Q68FG0, NP_061154.1|
|Calculated MW||26244 Da|
|Other Names||Zinc finger C4H2 domain-containing protein, Hepatocellular carcinoma-associated antigen 127, ZC4H2, HCA127, KIAA1166|
|Target/Specificity||This ZC4H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-224 amino acids from the C-terminal region of human ZC4H2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZC4H2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in interneurons differentiation (PubMed:26056227). Involved in neuronal development and in neuromuscular junction formation.|
|Cellular Location||Cytoplasm. Nucleus. Cell junction, synapse, postsynaptic cell membrane. Note=Upon transfection into mouse primary hippocampal neurons, localizes at excitatory, but not inhibitory, postsynaptic sites|
|Tissue Location||Expressed in fetal tissues, including in brain, intestine, lung, kidney and muscle (PubMed:23623388) Isoform 1 is expressed in numerous fetal brain regions. Isoform 3 is highly expressed in numerous fetal brain regions and spinal cord (PubMed:26056227).|
Provided below are standard protocols that you may find useful for product applications.
This protein contains a C4H2-type zinc finger and is thought to be involved in zinc ion binding. There are 3 isoforms produced by alternative splicing.
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Wang, Y., et al. J. Immunol. 169(2):1102-1109(2002)