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>   首页   >   产品   >   一抗   >   信号转导   >   ARHGAP17 Antibody (N-term)   

ARHGAP17 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ARHGAP17 Antibody (N-term) AP10759a
    ARHGAP17 Antibody (N-term) (Cat. #AP10759a) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ARHGAP17 antibody detected the ARHGAP17 protein (arrow).
  • 4 - ARHGAP17 Antibody (N-term) AP10759a
    ARHGAP17 Antibody (N-term) (Cat. #AP10759a) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • 14 - ARHGAP17 Antibody (N-term) AP10759a
    Formalin-fixed and paraffin-embedded H.placenta tissue reacted with ARHGAP17 Antibody (N-term) (Cat#AP10759a).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, FC, E
Primary Accession Q68EM7
Other Accession Q99N37, Q3UIA2, NP_001006635.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 95437 Da
Additional info
Gene ID 55114
Other Names Rho GTPase-activating protein 17, Rho-type GTPase-activating protein 17, RhoGAP interacting with CIP4 homologs protein 1, RICH-1, ARHGAP17, RICH1
Target/Specificity This ARHGAP17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-70 amino acids from the N-terminal region of human ARHGAP17.
Dilution WB~~1:1000
FC~~1:10~50
IHC-P~~1:100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsARHGAP17 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARHGAP17
Synonyms RICH1
Function Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.
Cellular Location Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact
Tissue Location Ubiquitously expressed. Expressed at higher level in heart and placenta.
Research Areas

BACKGROUND

RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM].

REFERENCES

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Wells, C.D., et al. Cell 125(3):535-548(2006)
Richnau, N., et al. J. Biol. Chem. 276(37):35060-35070(2001)
Reczek, D., et al. J. Cell Biol. 153(1):191-206(2001)

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