|Application ||IHC-P, WB, E|
|Other Accession||Q62381, NP_036596.3|
|Calculated MW||114709 Da|
|Other Names||Tolloid-like protein 1, 3424-, TLL1, TLL|
|Target/Specificity||This TLL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 874-901 amino acids from the C-terminal region of human TLL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TLL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.|
Provided below are standard protocols that you may find useful for product applications.
This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. A similar protein in mice is required during heart development and specifically processes procollagen C-propeptides and chordin at similar cleavage sites.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Berry, R., et al. FEBS Lett. 584(4):657-661(2010)
Sabirzhanova, I.B., et al. Biochem. Biophys. Res. Commun. 389(2):338-342(2009)
Stanczak, P., et al. Eur. J. Hum. Genet. 17(3):344-351(2009)
Mac Sweeney, A., et al. J. Mol. Biol. 384(1):228-239(2008)