注册 | 登录
所有产品
  • 所有产品
  • 一抗
  • 裂解液
>   首页   >   产品   >   一抗   >   信号转导   >   ORMDL3 Antibody (Center)   

ORMDL3 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ORMDL3 Antibody (Center) AP10739c
    All lanes : Anti-ORMDL3 Antibody (Center) at 1:1000 dilution Lane 1: Jurkat whole cell lysate Lane 2: mouse testis lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 17 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 产品详情
  • 文献引用 : 4
  • 实验流程
  • 背景知识
Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q8N138
Other Accession Q6QI25, Q9CPZ6, Q5XJR6, Q0VD15, Q9CQZ0, Q53FV1, Q5E972, Q5XH57, Q9P0S3, Q8JFB7, Q29RQ9, NP_644809.1
Reactivity Human, Mouse
Predicted Rat, Zebrafish, Bovine, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 94103
Other Names ORM1-like protein 3, ORMDL3
Target/Specificity This ORMDL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-81 amino acids from the Central region of human ORMDL3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsORMDL3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ORMDL3
Function Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.
Cellular Location Endoplasmic reticulum membrane; Multi- pass membrane protein
Tissue Location Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus
Research Areas
Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine.
Author : Maekawa M1,Lee M1,2,Wei K1,Ridgway ND3,Fairn GD1,2,4.
Sci Rep. 2016 Nov 2;6:35762. doi: 10.1038/srep35762.
27805006
ORMDL proteins regulate ceramide levels during sterile inflammation.
Author : Cal L1, Oyeniran C2, Biwas DD3, Allegood J2, Milstien S4, Kordula T2, Maceyka M2, Spiegel S5.
J Lipid Res. 2016 Jun 16. pii: jlr.M065920. [Epub ahead of print]
27313060
ORMDL3 modulates store-operated calcium entry and lymphocyte activation.
Author : Carreras-Sureda A1, Cantero-Recasens G, Rubio-Moscardo F, Kiefer K, Peinelt C, Niemeyer BA, Valverde MA, Vicente R.
Hum Mol Genet. 2013 Feb 1;22(3):519-30. doi: 10.1093/hmg/dds450. Epub 2012 Oct 25.
23100328
ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6.
Author : Miller M1, Tam AB, Cho JY, Doherty TA, Pham A, Khorram N, Rosenthal P, Mueller JL, Hoffman HM, Suzukawa M, Niwa M, Broide DH.
Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16648-53. doi: 10.1073/pnas.1204151109. Epub 2012 Sep 24.
23011799

BACKGROUND

Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

REFERENCES

Fransen, K., et al. Hum. Mol. Genet. 19(17):3482-3488(2010) Liu, X., et al. Nat. Genet. 42(8):658-660(2010) Halapi, E., et al. Eur. J. Hum. Genet. 18(8):902-908(2010) Dobbins, S.E., et al. Int. J. Cancer (2010) In press : McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)

FeedBack

终于等到您。感谢您使用ABGENT(百奇生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。

如有疑问,联系:0512-69552906 tech.abgent@wuxiapptec.com.


我要评价