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BEX1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - BEX1 Antibody (Center) AP10699c
    BEX1 Antibody (Center) (Cat. #AP10699c) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the BEX1 antibody detected the BEX1 protein (arrow).
  • 14 - BEX1 Antibody (Center) AP10699c
    BEX1 Antibody (Center) (Cat. #AP10699c) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the BEX1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 4 - BEX1 Antibody (Center) AP10699c
    BEX1 Antibody (Center) (Cat. #AP10699c) flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, FC, IHC-P, E
Primary Accession Q9HBH7
Other Accession Q9BXY8, Q2PG52, NP_060946.3
Reactivity Human
Predicted Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 55859
Other Names Protein BEX1, Brain-expressed X-linked protein 1, BEX1
Target/Specificity This BEX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the Central region of human BEX1.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBEX1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BEX1
Function Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).
Cellular Location Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus.
Tissue Location Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia.
Research Areas

BACKGROUND

Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).

REFERENCES

Ding, K., et al. Carcinogenesis 30(1):35-42(2009)
Foltz, G., et al. Cancer Res. 66(13):6665-6674(2006)
Alvarez, E., et al. Gene 357(1):18-28(2005)
Quentmeier, H., et al. Leukemia 19(8):1488-1489(2005)
Ross, M.T., et al. Nature 434(7031):325-337(2005)

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