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>   首页   >   产品   >   一抗   >   神经科学   >   PDE7B Antibody (C-term)   

PDE7B Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - PDE7B Antibody (C-term) AP10675b
    PDE7B Antibody (C-term) (Cat. #AP10675b) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the PDE7B antibody detected the PDE7B protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9NP56
Other Accession NP_061818.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51835 Da
Additional info
Gene ID 27115
Other Names cAMP-specific 3', 5'-cyclic phosphodiesterase 7B, PDE7B
Target/Specificity This PDE7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 421-450 amino acids from the C-terminal region of human PDE7B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPDE7B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDE7B
Function Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.
Tissue Location Highly expressed in brain. Also expressed in heart, liver, skeletal muscle and pancreas
Research Areas

BACKGROUND

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.

REFERENCES

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kestenbaum, B., et al. J. Am. Soc. Nephrol. 21(7):1223-1232(2010)
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Ikeda, M., et al. Biol. Psychiatry 67(3):263-269(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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