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>   首页   >   产品   >   一抗   >   癌症   >   BRIP1 Antibody (N-term)   

BRIP1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - BRIP1 Antibody (N-term) AP10665a
    BRIP1 Antibody (N-term) (Cat. #AP10665a) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the BRIP1 antibody detected the BRIP1 protein (arrow).
  • 1 - BRIP1 Antibody (N-term) AP10665a
    BRIP1 Antibody (N-term) (Cat. #AP10669c) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the BRIP1 antibody detected the BRIP1 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9BX63
Other Accession NP_114432
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 83990
Other Names Fanconi anemia group J protein, Protein FACJ, ATP-dependent RNA helicase BRIP1, BRCA1-associated C-terminal helicase 1, BRCA1-interacting protein C-terminal helicase 1, BRCA1-interacting protein 1, BRIP1, BACH1, FANCJ
Target/Specificity This BRIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-163 amino acids from the N-terminal region of human BRIP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBRIP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BRIP1
Synonyms BACH1, FANCJ
Function DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.
Cellular Location Nucleus.
Tissue Location Ubiquitously expressed, with highest levels in testis.
Research Areas

BACKGROUND

BRIP1 is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1).

REFERENCES

Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Bailey, S.D., et al. Diabetes Care (2010) In press :
Solyom, S., et al. Fam. Cancer (2010) In press :
Xie, J., et al. Oncogene 29(17):2499-2508(2010)
Smith, I.M., et al. ORL J. Otorhinolaryngol. Relat. Spec. 72(1):44-50(2010)

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